Helical peptide–polyamine and –polyether conjugates as synthetic ionophores
نویسندگان
چکیده
منابع مشابه
Trace Level Determination of Polyether Ionophores in Feed
A liquid chromatography-mass spectrometric method was developed and validated to determine six polyether ionophores (lasalocid sodium, monensin sodium, salinomycin sodium, narasin, maduramicin ammonium alpha, and semduramicin sodium) in feed samples. The method developed was very straightforward, involving extraction with 84% acetonitrile of the coccidiostats from the feed samples and filtratio...
متن کاملEvaluation of Polyether Ionophores against Coccidiosis in Broiler Chicken
The efficacy of three polyether ionophores viz. salinomycin, monensin and maduramicin was evaluated in poultry. Dayold chicks (n=350) were randomly divided into seven groups of 50 chicks each. The drugs were administered as feed premix from day one onwards. The chicks at 14-day of age were initially infected with 20,000 sporulated viable oocysts of Eimeria tenella and challenged with 40,000 spo...
متن کاملCyPLOS: a new family of synthetic ionophores.
The ion transport properties of a new family of synthetic ionophores based on cyclic phosphate-linked oligosaccharide (CyPLOS) macrocycles are described.
متن کاملPeriodicity in collision-induced and remote-bond activation of alkali metal ions attached to polyether ionophores.
The collision-induced dissociation of lasalocid and monensin A bound to alkali metal cations has been investigated using electrospray MS/MS. The binding affinity for the metal cations, as measured with collision-induced dissociation, was found to depend on their ionic radius, decreasing with increasing radius. Monensin A was observed to have a greater binding affinity for alkali metal cations t...
متن کاملInhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.
Cryptosporidicidal effects of two polyether ionophores (maduramicin and alborixin), a fluorinated 4-quinolone (enrofloxacin), and three analogs of pentamidine were evaluated in a suckling mouse bioassay. Treatment with all compounds except enrofloxacin and one of the pentamidine analogs [1,3-di(4-imidazolinophenoxy)propane] resulted in significant (P less than 0.05) reductions in oocyst excretion.
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2015
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2015.10.034